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Wednesday, November 13, 2024

SafeandHealthylife

What to Do if You’re a Victim of Medical Malpractice

Being a medical malpractice victim is beyond overwhelming. If you’re in a tough place and your trust is broken, you just feel lost and frustrated, so you have to know how to protect your rights and get the help you deserve. What is Medical Malpractice? Medical malpractice is described as a health care provider who […]

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11 Things to Expect When You Stop Drinking Alcohol

There are so many reasons that people give up alcohol revamping their diet, or something more serious like being proactive about a potential problem. No matter why the benefits come with a lot of effort, and in the end, it will pay off. There will be good days, there will be bad days, and there […]

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10 Common Signs of Anxiety and How to Treat Them

Anxiety affects approximately 1 in 13 people worldwide or 7.3% of the global population. As more public figures like Lady Gaga and Ryan Reynolds share their experiences with anxiety, the condition is increasingly normalized and destigmatized. Recognizing the signs of anxiety can help you seek the right treatment. Anxiety can manifest several symptoms of both […]

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4 Helpful Ways to Boost Men’s Hormonal Health

Men’s hormonal health is a major determinant of overall well-being; it influences everything, including mood and energy level, physical strength, and mental clarity. Deficient testosterone and hormonal abnormalities may greatly affect everyday living and cause symptoms like weariness, irritation, and lower physical endurance. Proactive management of hormonal health can have wide-ranging benefits by helping to […]

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How You Can Recover From Trauma

Trauma shakes your foundation. It could be accident-related, loss-related, or any challenging period; it’s heavy and very time-consuming. Recovery here does not only mean healing but also reconstructing your life. There are tracks people have traditionally followed to navigate recovery, which may work for you, too. How You Can Recover From Trauma Knowing these tracks […]

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10 Creative Ways to Help Your Children Exercise

Every parent wants their child to grow up healthy and active, but with screens and indoor entertainment, getting kids to exercise can be challenging. Unhealthy weight gain in children can increase their risk of cardiovascular diseases, diabetes, and other chronic health conditions later in life (CDC). The earlier you can start a pattern of healthy […]

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How to Improve Your Mental Fitness: Simple Strategies for a Healthier Mind

In today’s fast-paced world of information, it’s not uncommon for people to have issues with their mental state. Stress is a major factor in causing problems in one’s mind, and this can often lead to even bigger problems. Overworking yourself without giving yourself some time to rest can also have such an impact. Mental fitness […]

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Private MRI Scans: What Are They and When Should You Consider One?

Magnetic Resonance Imaging (MRI) is a powerful diagnostic tool used to capture detailed images of the body’s internal structures. MRI scans are non-invasive and use strong magnetic fields and radio waves to create highly detailed images, helping doctors diagnose a wide range of conditions. In many healthcare systems, including the NHS in the UK, access […]

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De Quervain’s Tenosynovitis: Causes, Symptoms & Treatment

If you have ever experienced a sharp pain in your wrist that stopped you in your tracks, you may have been suffering from De Quervain’s disease. This common disease has been known to affect many young adults at one stage in their lives and can be extremely painful. The condition needs to be medically diagnosed and […]

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What To Know Before Getting Treatment At A Drug Treatment Center

The decision to seek help for overcoming addiction becomes one of the most significant steps toward recovery. It’s a rather challenging process, mostly coupled with uncertainty and doubts. Thus, to make this journey smoother and more effective, knowing what to expect and what to consider before going to a drug treatment center will be very […]

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Rosanna Davison Nutrition

How Thoughtful Meal Planning is Vital in Senior Care

Nutrition is a cornerstone of health, and for seniors, a well-balanced diet plays an even more crucial role. The older you get, the more your body changes, as does the nutrition required for it. In senior care communities, thoughtful meal planning goes beyond simply providing food; it’s about creating nutritious, appealing, and supportive meals that […]

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How Good Nutrition Supports Longevity

Good nutrition is vital for promoting longevity and enhancing quality of life. As scientific understanding of nutrition has advanced, so has the recognition of diet’s profound impact on health, disease prevention, and the natural ageing process. A balanced, nutrient-rich diet provides the essential building blocks for the body’s functions, while also helping to stave off […]

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Embracing Natural Solutions for Pain Management

Chronic pain is a common concern that affects people from all backgrounds, ranging from active athletes to those managing daily tasks. While many individuals often rely on over-the-counter medications for immediate relief, a growing number are turning to natural remedies as a viable alternative. The Benefits of Going Natural Opting for natural remedies for pain […]

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Areas You Didn’t Know You Could Outsource For A Stress-Free Move

Moving to a new home can be one of life’s most stressful events. Between packing up your entire life, coordinating logistics, and adjusting to a new environment, it’s easy to become overwhelmed. While many people are aware of traditional moving services, such as packing and transporting belongings, there are several lesser-known areas where outsourcing can […]

The post Areas You Didn’t Know You Could Outsource For A Stress-Free Move appeared first on Rosanna Davison Nutrition.

Your Guide to Post-Baby Body Confidence

Becoming a mother is a transformative experience, both emotionally and physically. While the joy of welcoming a new life is unparalleled, many women struggle with the changes their bodies go through post-pregnancy. It’s natural to feel self-conscious or disconnected from your new body. However, embracing post-baby body confidence is possible, and it starts with understanding […]

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The Vital Role of Nutrition in Addiction Treatment

Addiction treatment is a multifaceted process that will look into the physical, emotional, and psychological needs of individuals seeking recovery. While therapies and medications are often the primary focus, nutrition plays a vital but sometimes overlooked role in the overall success of addiction treatment. Proper nutrition can support the healing process, restore physical health, and […]

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Staying Fit as You Age: A Guide to a Healthier Later Life

Though it is an inevitable process, how you choose to age is primarily up to you. Keeping fit in one’s golden years means everything for enjoying life at a higher rate. Also, fitness isn’t only about being healthy but also ensures mental clarity and a good mood. Let’s go through some of these strategies that’ll […]

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Foods to Avoid for Healthy Teeth

Maintaining excellent oral health is vital for overall well-being, and your diet plays a key role in achieving this. While we often focus on foods that promote good dental health, it’s equally important to be aware of those that can harm your teeth. Here’s a look at some key foods and drinks you should consider […]

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How to Pack Light on Your Next Summer Vacation and Still Look Fabulous

It’s summer. It’s time to party – or at least, time to get out of your routine and go somewhere new. If you’re on a budget, however, then you’re taking every cost-cutting corner you can take, and sometimes that means going with carry-on luggage online. Sometimes still it means only bringing a personal item to […]

The post How to Pack Light on Your Next Summer Vacation and Still Look Fabulous appeared first on Rosanna Davison Nutrition.

The Rise of Customised Home Decor

Home decor has always been a reflection of personal style and taste. However, in recent years, the trend of customised home decor has taken the world by storm. This shift towards personalised design transforms houses into unique sanctuaries that echo their inhabitants’ distinct personalities and stories. From bespoke furniture to tailored wall art, customized home […]

Monday, October 28, 2024

PMA treatment of cultured HBCs induces in vivo activation genes

We next compared the gene expression of HBCs activated via PMA in vitro and HBCs activating natively under injury conditions in vivo. Given the potential wide-ranging effects of PMA on cultured cells, we assessed transcriptomic similarity using specific established marker genes and by analyzing the expression of entire gene sets. For our in vivo reference, we re-analyzed a single-cell dataset of resting and activated HBCs from the injured, regenerating wild-type mouse OE harvested at multiple time points after MTZ injury (Gadye et al., 2017).

We clustered Krt5(+) HBCs from the Gadye dataset into three groups based on their expression of three marker genes: dormancy regulator Tp63, proliferation marker Mki67, and activation marker Hopx. Hopx was additionally chosen in part because of its known role in cellular differentiation in other tissues (Hng et al., 2020; Palpant et al., 2017). These markers identify three developmentally sequential HBC subpopulations: Tp63(+) resting HBCs, Mki67(+) transitioning/ cycling HBCs, and Hopx(+) fully activated HBCs (Figure 2A). A set of ten candidate genes that were highlighted by Gadye as key during the regeneration process in vivo were mapped onto the re-analyzed, native HBC UMAP (Uniform Manifold Approximation and Projection) to highlight the gene list’s correlation with HBC status in vivo, confirming the clustering into three subpopulations (Figure 2B). In keeping with the in vivo analysis, PMA-activated HBCs demonstrated, by immunostaining, an inverse correlation between increasing HOPX protein and decreasing TP63 protein at 12 HPT (Figure 2C).

This result is corroborated by prior work demonstrating enrichment of HOPX in human keratinocytes following PMA treatment (Yang et al., 2010). In contrast with the results in vivo, HOPX labeled a very high percentage of the PMA-activated HBCs. Nonetheless, PMA treatment does induce a specific state highly analogous to in vivo injury-activated HBCs. Using the module detection function of Seurat (Tirosh et al., 2016), we plotted the collective expression of the top 100 DEGs induced by PMA treatment, including both 6 HPT and 12 HPT sets given the high degree of concordance between the sets (Figure S2).

Expression of this signature was highly elevated in the same in vivo-activated HBC cluster (Figure 2D), reaffirming transcriptomic similarity between PMA-activated HBCs in vitro and injury-activated HBCs in vivo. Importantly, while the PMA-induced gene set was enriched for signaling, development, and differentiation GO terms (Figure 2E), only one gene overlapped with the previously published wound-response gene set (Sprr1a), thus indicating broader transcriptomic similarity between the two activated HBC populations.

We examined the overrepresented ontology categories across five distinct HBC populations to compare changes between in vitro and in vivo activation more comprehensively: PMA-treated HBCs in vitro (6 HPT and 12 HPT) and in vivo post-injury HBCs (resting, HBC*1, and HBC*2, the latter two representing the two stages of activated HBCs) (Gadye et al., 2017).

All five HBC populations show upregulation of various epithelial remodeling categories. In addition, all five HBC populations show downregulation of developmental, microtubule polymerization, and neuron projection categories. PMA-treated HBCs, irrespective of length of treatment, could be defined by overlapping upregulated and downregulated ontology categories.

Advanced human embryo research beyond the 14-day limit: A bioethical perspective from the Muslim world

This article highlights the overlooked Islamic perspectives on the 14-day rule in international guidelines for human embryo research, predominantly shaped by Western, secular traditions. Despite their global influence, these guidelines constrain Muslim-majority countries, where Islamic perspectives hold more permissive views. Recent developments underscore the urgent need for a more inclusive discourse, especially as Muslim countries increasingly invest in research institutions and collaborate with their Western counterparts.

Religiously rooted bioethical perspectives are also gaining prominence, exemplified by the 17th World Congress of Bioethics in Doha, Qatar, which took place on 3–6 June 2024. This event marks the first edition hosted in the Arab world and the entire Middle East, centered on the theme ‘‘Religion, Culture, and Global Bioethics’’ (https:// wcb.cilecenter.org/wcb#/?lang=en). Significant strides in human embryo research and discussions reflect centuries-old interactions between science and ethics, shaping our understanding of the human body and the broader universe. Figures like Aristotle (d. 322 BCE), Avicenna (1037), Maimonides (1204), and Aquinas (d. 1274) have profoundly shaped both developmental biology and ethical considerations.

Muslim scholars have similarly engaged critically with these interdisciplinary sources, verifying religio-ethical positions on human embryos (Ghaly, 2014). Amid shifting paradigms in modern biomedical advancements, particularly embryo research, the Muslim world’s discussions have consistently integrated Islamic values, advocating for nuanced approaches rooted in pre-modern Islamic scholarship. HUMAN EMBRYO IN THE ISLAMIC MORAL TRADITION To explore contemporary Islamic perspectives on embryo research and elucidate their methodological foundations and modes of reasoning, this article begins with an overview of pertinent pre-modern discussions, followed by an examination of contemporary perspectives. Drawing from dominant positions in classical and modern discourse, we then propose an engaging perspective that integrates these historical and current viewpoints. Pre-modern discourse Analyses from early Muslim scholars indicate that an in vivo embryo was typically perceived as part of the unseen world (ghayb), knowledge of which is exclusive to God and primarily conveyed through the Quran and Sunna. They also acknowledged empirically verified medical information as a valid source of knowledge, aiming to reconcile insights from diverse sources, grounded in the belief that God is the ultimate source of both medical knowledge and religious scripture.

The moral standing of the human embryo was not fixed but subject to change based on three key factors. Place Some canonical Prophetic traditions explicitly describe the embryo as a fusion of two fluids, literally waters (in Arabic maʾan ), one from the male and the other from the female. Based on the medical knowledge available at the time, pre-modern Muslim scholars viewed a woman’s womb as the sole environment where this mixture of fluids (fertilized egg) could exist and develop until birth. Grounded in these scriptural references and medical understanding, Muslim scholars concurred that the initial morally significant status of a human embryo begins with its implantation in the womb. While male and female fluids could exist separately outside the womb, neither had the potential to independently progress to the stage of a viable embryo or

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Wednesday, October 23, 2024

Essential Oil Benefits

Shift In MarTech Usage, AI Perceptions, Among Findings In WealthStack Study
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Impulse initiation in engrafted pluripotent stem cell-derived cardiomyocytes can stimulate the recipient heart
Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening
Human microglial cells as a therapeutic target in a neurodevelopmental disease model
Human microglia-derived proinflammatory cytokines facilitate human retinal ganglion cell development and regeneration
An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase
Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models
Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed
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